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OALib Journal期刊

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Patient-Reported Outcomes of Surgery of Non-Small Cell Lung Cancer: Evaluation Based on the Questionnaires of Anti-Aging Quality of Life and the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire  [PDF]
Takanori Ayabe, Masaki Tomita, Naohiro Nose, Takashi Asada, Kunihide Nakamura
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.85024
Abstract: Background: Patient-reported outcomes of the quality of life (QOL) after an open thoracotomy have not been studied. To determine the physical and mental changes in surgical patients is very important for medical staffs. The surgical patient’s satisfaction and overall healthy changes were evaluated by the patient-self assessment questionnaires. Materials and Methods: From July 2007 to April 2008, 26 patients with non-small cell lung cancer (NSCLC) underwent surgical resection. The outcome of the QOL was evaluated by using two kinds of questionnaire surveys from the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and the anti-aging QOL assessment (AA-QOL). The EORTC QLQ-C30 consisted of five domains (physical, role, cognitive, emotional, and social functionings) and global QOL. The AA-QOL contained 51 items; 30 physical and 21 mental symptoms regarding the elderly and the aging population. The patients replied to the two questionnaires at two different times, i.e., at pre-surgery (baseline) and at post-surgery (2 weeks after the operation). The obtained data of these scores were averaged and compared between the two points of the pre-surgery and post-surgery. Results: Regarding the outcomes of the EORTC QLQ-C30, the physical and social functioning became significantly worse after the surgery. In contrast, the global QOL significantly became better after the surgery. For the symptom at post-surgery, three of which were “nausea and vomiting”, “pain”, and “appetite loss”, became significantly worse compared to those at pre-surgery. Regarding the outcomes of the AA-QOL, the physical symptoms (muscular pain/stiffness, palpitations, dyspnea, no feeling of good health, anorexia, and coughing and sputum) became significantly worse after the surgery. Regarding the mental symptoms, there were no significant differences. Conclusions: Regarding the outcomes based on the changes in the QOL after surgery, the physical symptoms became worse compared to the mental symptoms. To clarify the perioperative healthy changes of the QOL reported by patients with lung cancers is very important for multidisciplinary teamwork, which should play a role in providing the appropriate care and treatment and useful information for a preoperative patient’s decision making of receiving surgical treatment.
Distances in Inhomogeneous Cosmological Models
Kenji Tomita,Hideki Asada,Takashi Hamana
Physics , 1999, DOI: 10.1143/PTPS.133.155
Abstract: Distances play important roles in cosmological observations, especially in gravitational lens systems, but there is a problem in determining distances because they are defined in terms of light propagation, which is influenced gravitationally by the inhomogeneities in the universe. In this paper we first give the basic optical relations and the definitions of different distances in inhomogeneous universes. Next we show how the observational relations depend quantitatively on the distances. Finally, we give results for the frequency distribution of different distances and the shear effect on distances obtained using various methods of numerical simulation.
Images for an Isothermal Ellipsoidal Gravitational Lens from a Single Real Algebraic Equation
Hideki Asada,Takashi Hamana,Masumi Kasai
Physics , 2002, DOI: 10.1051/0004-6361:20021599
Abstract: We present explicit expressions for the lens equation for a cored isothermal ellipsoidal gravitational lens as a single real sixth-order algebraic equation in two approaches; 2-dimensional Cartesian coordinates and 3-dimensional polar ones. We find a condition for physical solutions which correspond to at most five images. For a singular isothermal ellipsoid, the sixth-order equation is reduced to fourth-order one for which analytic solutions are well-known. Furthermore, we derive analytic criteria for determining the number of images for the singular lens, which give us simple expressions for the caustics and critical curves. The present formulation offers a useful way for studying galaxy lenses frequently modeled as isothermal ellipsoids.
Preoperative Serum Krebs Von Den Lungen-6 and Surfactant Protein-D Levels in Non-Small Cell Lung Cancer Patients with Interstitial Pneumonia  [PDF]
Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Takashi Asada, Kazuyo Tsuchiya, Kunihide Nakamura
Open Journal of Thoracic Surgery (OJTS) , 2017, DOI: 10.4236/ojts.2017.71001
Abstract: We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) surfactant protein-D (SP-D) levels in non-small cell lung cancer (NSCLC) patients with interstitial pneumonia (IP). We enrolled 41 NSCLC patients with IP who have undergone curative surgery. Prognostic significance of serum KL-6 and SP-D levels was examined. We found a significant relationship between serum KL-6 and SP-D levels in NSCLC patients with IP. However, the 5-year survival of patients with high serum KL-6 level was poor, whereas serum SP-D level was not related to patients’ survival. Univariate analysis revealed that there was a trend towards an association between serum KL-6 level and patients’ prognosis but this did not reach statistical significance. This might be due to small number of study patients. In conclusion, there is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of IP.
Patient-Reported Outcomes of Chemotherapy Involving Non-Small Cell Lung Cancer: Evaluation by Questionnaires of Quality of Life Regarding Anti-Aging and Anti-Cancer Drugs  [PDF]
Takanori Ayabe, Masaki Tomita, Takashi Asada, Kazuyo Tsuchiya, Manabu Nemoto, Kunihide Nakamura
Advances in Lung Cancer (ALC) , 2017, DOI: 10.4236/alc.2017.62002
Abstract: Background: Patient-reported outcomes (PROs) of quality of life (QOL) during chemotherapy involving lung cancer are very important for the medical staffs. Patients’ satisfaction and healthy changes were evaluated by the patient-self assessment. Materials and Methods: From July 2007 to April 2008, a total of 19 patients received chemotherapy. The QOL data were collected by using the QOL questionnaire for cancer patients treated with anticancer drugs (QOL-ACD) and the anti-aging QOL assessment (AA-QOL). The AA-QOL contained 51 items: 30 of physical and 21 of mental symptoms of the elderly and the aging population. The patients replied to the questions at two different times, i.e., at pre-chemotherapy (baseline) and at post-chemotherapy (2 weeks after the chemotherapy). Results: Regarding the hematological toxicities, for the grade 3/4 toxicities, there were 12 neutropenia (12/19, 63.2%) and 3 thrombocytopenia (3/19, 15.8%). For the grade 3 febrile neutropenia, there were 5 cases (5/19, 26.3%). Regarding the non-hematological toxicities, there was no grade 3 and grade 4 toxicities. Based on the outcomes of the QOL-ACD, the three items (“physical condition”, “social attitude”, and “overall QOL”) at post-chemotherapy became significantly worse compared to the baseline. Regarding the outcomes of the AA-QOL, 4 items of physical symptoms (“thirst”, “anorexia”, “early satiety”, and “diarrhea”) became significantly worse compared to the baseline. Regarding the mental symptoms, 2 items (“nothing to look forward in life” and “a sense of uselessness”) became significantly worse compared to the baseline. Conclusion: Regarding the PROs of the QOL during the chemotherapy term, both the physical and mental symptoms had become worse. To clarify the changes in the QOL during chemotherapy is very important for multidisciplinary teamwork, which should play the role of providing the appropriate cares and treatment as patient-support.
Lin4Neuro: a customized Linux distribution ready for neuroimaging analysis
Kiyotaka Nemoto, Ippeita Dan, Christopher Rorden, Takashi Ohnishi, Daisuke Tsuzuki, Masako Okamoto, Fumio Yamashita, Takashi Asada
BMC Medical Imaging , 2011, DOI: 10.1186/1471-2342-11-3
Abstract: The boot time of this system was only around 40 seconds. We performed a benchmark test of inhomogeneity correction on 10 subjects of three-dimensional T1-weighted MRI scans. The processing speed of USB-booted Lin4Neuro was as fast as that of the package installed on the hard disk drive. We also installed Lin4Neuro on a virtualization software package that emulates the Linux environment on a Windows-based operation system. Although the processing speed was slower than that under other conditions, it remained comparable.With Lin4Neuro in one's hand, one can access neuroimaging software packages easily, and immediately focus on analyzing data. Lin4Neuro can be a good primer for beginners of neuroimaging analysis or students who are interested in neuroimaging analysis. It also provides a practical means of sharing analysis environments across sites.The flourishing development of the neuroimaging research field has been in part supported by a wealth of open-source software packages released from various laboratories worldwide. Besides the obvious merit of being available for free, they are often equipped with cutting-edge analytical tools that are not included in commercial software packages, allowing researchers to perform state-of-the-art neuroimaging analyses.These packages are usually developed for a specific purpose, but many researchers use them in combination. For example, Acosta-Cabronero et al. [1] demonstrated that the combination of skull stripping with BET2 [2] and intensity inhomogeneity correction with N3 [3] improved the accuracy of the gray matter segmentation of SPM5 [4].Conventionally, UNIX or UNIX-like operating systems such as Linux have served as platforms for developing most of these software packages. However, not all researchers in the field of neuroimaging are familiar with those versatile yet recondite operating systems. This is especially so given the interdisciplinary development of neuroimaging research, which inevitably entails the influx of
Prevalence of childhood obstructive sleep apnea syndrome and its role in daytime sleepiness
Aiko Moriwaki,Eriko Tsukada,Kazuo Mishima,Minori Enomoto,Shingo Kitamura,Takashi Asada,Tetsuaki Arai,Yoko Kamio
- , 2018, DOI: 10.1371/journal.pone.0204409
Abstract:
Post-fracture Rehabilitation Effects on Brain Function in Older People
Kanehito Morimoto,Katsuya Urakami,Mieko Tanaka,Minoru Kouzuki,Noriko Mitsuboshi,Takashi Asada,Yohei Kobayashi
- , 2019, DOI: 10.33160/yam.2019.03.009
Abstract: pj.oc.oohay@nnaynahcca
Nonlinear Acoustic Shadow Method to Reduce Reverberation Artifact  [PDF]
Kei Fujisawa, Akira Asada
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2016, DOI: 10.4236/jfcmv.2016.42005
Abstract: A novel technique for reducing reverberation artifact in acoustic shadow imaging using nonlinear ultrasound interaction, called nonlinear acoustic shadow method, has been developed and experimentally studied. In this technique, the conventional acoustic shadow method is modified by using the secondary wave generated by nonlinear interaction of two primary sound waves emitted from parametric array. Either conventional or nonlinear acoustic shadow imaging is carried out for aluminum square cylinder and the size of the shadow is compared. The result shows that the nonlinear acoustic shadow method reduces reverberation artifact inside the square cylinder and has better accuracy in the size measurement than conventional acoustic shadow method.
Thermodynamic and Transport Properties of CeMg2Cu9 under Pressure
Masakazu Ito,Koji Asada,Yuko Nakamori,Jyun'ya Hori,Hironobu Fujii,Fumihiko Nakamura,Toshizo Fujita,Takashi Suzuki
Physics , 2004, DOI: 10.1143/JPSJ.73.2252
Abstract: We report the transport and thermodynamic properties under hydrostatic pressure in the antiferromagnetic Kondo compound CeMg2Cu9 with a two-dimensional arrangement of Ce atoms. Magnetic specific heat Cmag(T) shows a Schottky-type anomaly around 30 K originating from the crystal electric field (CEF) splitting of the 4f state with the first excited level at \Delta_{1}/kB = 58 K and the second excited level at \Delta_{2}/kB = 136 K from the ground state. Electric resistivity shows a two-peaks structure due to the Kondo effect on each CEF level around T_{1}^{max} = 3 K and T_{2}^{max} = 40 K. These peaks merge around 1.9 GPa with compression. With increasing pressure, Neel temperature TN initially increases and then change to decrease. TN finally disappears at the quantum critical point Pc = 2.4 GPa.
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